Table of Contents
HGH or human growth hormone, is produced by the pituitary gland of the brain.
It’s responsible for growth and development not only of long bones that contribute to stature, but in conjunction with insulin-like growth factor-1 manufactured in liver.
IGF-1 is a vital component to the growth of all types of cells in the body.
Growth factors and hormones are not just responsible for growth, but are involved in a number of metabolic processes, in establishing body composition, fat to muscle mass ratios, and even brain functions.
Growth hormone deficiency technologies were developed in the latter half of the 1950s, and development continued into the late 1980s.
Originally, HGH extractions were performed on the pituitary glands of deceased individuals during an autopsy. Biochemists would then work to “grow” and purify the growth hormone for eventual use in a growth hormone deficiency treatment plan using HGH injections.
As with any new discovery or technology, advancements continued. In the 1960s, the National Institutes of Health’s National Pituitary Agency was charged with supervision of collection of human cadaver for pituitary glands during autopsies.
Because of the lack of availability and due to the fact that cadaver HGH was extremely limited in regard to supply, only the most severely affected children were treated.
Between the 1960s and mid-1980s, tens of thousands of children were treated with cadaver growth hormone. While HGH extractions were not prevalently known outside of the circle of individuals involved in such therapies, research continued.
By the mid-1970s, supplies of cadaver growth hormone decreased. This was due to growing concerns that HGH extractions from human cadavers had the possibility of increasing the risk for Creutzfeldt-Jakob disease (mad cow disease). Other options were explored. Find out more here.
By the early 1980s, American-based Genentech began to develop what was to be called recombinant human growth hormone or rHGH utilizing recombinant DNA technologies.
This technology defines a process in which a human gene is implanted into a type of bacteria to create and grow proteins. Because of the link regarding HGH extractions to Creutzfeldt-Jakob disease , that form of growth hormone treatment pretty much fell out of favor and was gradually phased out.
As a result, the Food and Drug Administration approved Genentech’s rHGH, which became available in the United States as Protropin in 1985.
Protropin (trade name) was the first rHGH growth hormone product marketed. Then it was more commonly known as met-GH (methionyl growth hormone or Somatrem).
Today, synthetic growth hormone (somatropin) is available in over 24 brand or trade names around the world. And the rest, they say, is history. While HGH extractions from human cadavers are no longer a major source of synthetically produced growth hormone, they occupy a place in medical/technological pharmaceutical history.A more detailed history of the biotechnological development of growth hormone can be accessed via a Smithsonian article, “The big story behind synthetic human growth hormone”. An even older source of information regarding HGH extractions can be found in the 1948 issue of Life magazine (October 11).
While the number of individuals diagnosed with Creutzfeldt-Jakob disease have decreased significantly, many have been linked to HGH extractions and treatments from early years of development of growth hormone treatment plans. Controversy regarding its use continues.
Because of the link between the HGH extractions and brain disease as noted in Creutzfeldt-Jakob disease , concern has also been raised that this treatment plan might have also been a contributing factor for a number of elderly patients diagnosed with Parkinson’s or Alzheimer’s. That has been studied and discarded. However, amyotrophic lateral sclerosis or ALS is not yet in the clear.
★ ★ ★ ★ ★8 Customer Reviews
BUY 2, GET 1 Free
+ VIEW DETAILS
BUY NOW SEE RESULTS
I gained 4 kg of lean muscle! ★ ★ ★ ★ ★ Helped me gain 4 kg of lean muscle in 8 weeks. Strength has increased 10kg increase on deadlift 20kg increase squat.Callum D.
READ MY REVIEW
I lost 17 lbs of weight! ★ ★ ★ ★ ★ I dropped 17 lbs, with a complete change in my body composition. My strength has increased big time. Bob B.
READ MY REVIEWI gained 16 lb of muscle!
★ ★ ★ ★ ★
The gains and results I’ve seen from it are unreal. I gained a good 16lbs in 30 days while becoming leaner! I feel like a beast!
Roy H.READ MY REVIEWI got ripped and stronger!
★ ★ ★ ★ ★
I started to lose weigh in my stomach; my waist line declined for 5 cm. My chest and arms have grown significantly.
William F.READ MY REVIEW