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Bodybuilders, athletes, and those looking for natural methods to promote health and wellness often find new herbal products and nutritional supplements on shelves, but a relatively new product is slowly gaining attention in this area. Most bodybuilders and athletes have heard of IGF-1 or insulin-like growth factor-1. However, a product known as IGF-1 LR3 is also making waves. What should you know about this product and what makes it different from simple IGF-1? Are IGF-1 LR3 results effective when it comes to certain aspects of health and wellness? Most importantly, is it safe? Click here to buy HGH online now.
Table of Contents
IGF-1 LR3 Before and After Results
When looking for benefits and results of any product, it’s important to know what it is and how it is designed to function in the body. The same applies to IGF-1 LR3 results.
First, defining the product. IGF-1 is an abbreviation of insulin-like growth factor-1. Insulin-like growth factor-1 is manufactured in the liver.
It is synthesized and secreted when triggered by the presence of growth hormone, manufactured and secreted by the pituitary gland.
The liver manufactures several types of growth factors. Insulin-like growth factor-1 is most prevalent in the body following birth. IGF-1 LR3 is simply an abbreviation for long arginine 3-IGF-1, which basically defines the product as an analogue of human manufactured IGF-1, modified to include a 13 amino acid N-terminus extension.
IGF-1 is composed of 70 amino acids, a vital peptide required for growth in mammals. Long arginine 3-IGF-1, also known as IGF-1 LR3, is a synthetically created “version” of IGF-1 and differs from the original by the addition of 13 amino acids at its N terminus, creating a strand of 83 amino acids.
There is also a substitution in the third position of this string of glutamate acid for arginine. This modification or difference in regard to composition makes the ability of IGF proteins to blind less efficiently, increasing potency and half-life.
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What the heck does that mean? Basically it means that IGF-1 LR3 is a synthetic protein; one that has been lengthened from the analogue of insulin-like growth factor-1.
The pharmaceutical description of an analogue is a compound that may not necessarily resemble another compound in regard to structure but may be similar in regard to function. Find out more here.
IGF-1 LR3 Results – Too Good To Be True?
Basically, the “LR3” attached to the IGF-1 growth factor promotes its effect. IGF-1 LR3 is a member of the protein family of peptides.
Proteins are vital for cellular growth and development. However, long r 3-IGF-1 (IGF-1 LR3) is quite a bit stronger than IGF-1 alone, promoting increased function and efficacy. The analogue was created in a laboratory environment to increase biological activities of the IGF peptide.
What does this have to do with bodybuilders and athletes? Bodybuilders and athletes want larger muscles. IGF-1 LR3 increases response of cells to growth hormone. Think of it as a domino effect. Growth hormone is manufactured and secreted by the pituitary gland and released into the bloodstream.
In response, the liver manufactures and secretes IGF-1, which then encourages activities of cells. One of these activities is muscle growth. IGF-1 is one of the most powerful growth factors in the human body and contributes to hyperplasia, the medical definition of the formation or splitting of new muscle cells.
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Bottom line? IGF-1 LR3 is considered one of the most effective forms of IGF-1. In fact, the formula has been chemically altered so that it doesn’t bind to proteins. The addition of the amino acids and alteration of the chain has also increased its half-life to roughly 20 to 30 hours.
Best Time To Take IGF-1 LR3
Very few studies on anything but small animals has been conducted with IGF-1 LR3. Small studies (mice) have resulted in reports that it has the capability of controlling growth and development.
According to one research company, it can significantly increase cellular survival rates, inhibit cellular death pathways, increase the combination of protein production, and enhance cell longevity. It’s best to simply follow label instructions for the IGF-1 LR3 dosage and instructions on how to take IGF-1 LR3.
The research company that manufactures chemical products for laboratory research
also reports that results are noticeable in small animal studies. The research company defines IGF-1 and variations of IGF-1 as essential not only for regular growth, but the capability in developing muscle mass later in life.
What About IGF-1 Supplements?
IGF-1 LR3 log results from supplements are listed on product labels for their ability to:
- Enhance muscle growth
- Replenish and rejuvenate nerve tissue
- Burn fat
- Slow down protein breakdown
- Increase transportation of protein into cells
- Improve manufacture of white blood cells (immune system)
- Lower bad cholesterol levels
The catch? It’s not legal to purchase without a prescription. If you’re an athlete or bodybuilder considering use of IGF-1 LR3 peptide, make sure you know where your sporting organization, club, association, or the World Anti-Doping Agency (WADA) stands on its use. You may find that IGF-1 LR3 results are just not worth the risk.
References
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- Higuti E, Cecchi CR, Oliveira NA, Vieira DP, Jensen TG, Jorge AA, Bartolini P, Peroni CN. Growth responses following a single intra-muscular hGH plasmid administration compared to daily injections of hGH in dwarf mice. Curr Gene Ther. 2012 Dec;12(6):437-43.
- Lima GA, Gadelha MR, Strasburger CJ, Wu Z. Serum levels of 20K-hGH and 22K-hGH isoforms in acromegalic patients. Front Horm Res. 2010;38:87-93. doi: 10.1159/000318498. Review.
- Nass R, Pezzoli SS, Chapman IM, Patrie J, Hintz RL, Hartman ML, Thorner MO. IGF-I does not affect the net increase in GH release in response to arginine. Am J Physiol Endocrinol Metab. 2002 Oct;283(4):E702-10.
- Wideman L, Weltman JY, Hartman ML, Veldhuis JD, Weltman A. Growth hormone release during acute and chronic aerobic and resistance exercise: recent findings. Sports Med. 2002;32(15):987-1004. Review.
- Caruso JF, Coday MA, Monda JK, Ramey ES, Hastings LP, Marshall MR. Growth hormone levels after flywheel ergometer exercise: correlation with independent variables. Aviat Space Environ Med. 2009 Jul;80(7):610-4.
- Healy ML, Gibney J, Russell-Jones DL, Pentecost C, Croos P, Sönksen PH, Umpleby AM. High dose growth hormone exerts an anabolic effect at rest and during exercise in endurance-trained athletes. J Clin Endocrinol Metab. 2003 Nov;88(11):5221-6.
- Saugy M, Robinson N, Saudan C, Baume N, Avois L, Mangin P. Human growth hormone doping in sport. Br J Sports Med. 2006 Jul;40 Suppl 1:i35-9. Review.
- Lee SB, Park H, Koh J, Lee H, Kim J. Evaluation of the bioefficacy of a stabilized form of human growth hormone (SP-hGH). Horm Metab Res. 2013 Sep;45(10):722-7. doi: 10.1055/s-0033-1345126.
- Kniess A, Ziegler E, Thieme D, Müller RK. Intra-individual variation of GH-dependent markers in athletes: comparison of population based and individual thresholds for detection of GH abuse in sports. J Pharm Biomed Anal. 2013 Oct;84:201-8. doi: 10.1016/j.jpba.2013.06.008.
- ?ebrowska A, Wa?kiewicz Z, Zaj?c A, G?sior Z, Galbo H, Langfort J. IGF-1 response to arm exercise with eccentric and concentric muscle contractions in resistance-trained athletes with left ventricular hypertrophy. Int J Sports Med. 2013 Feb;34(2):116-22. doi: 10.1055/s-0032-1321720.
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