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Synthetically created rHGH, at least in its function, works the same as endogenous growth hormone. The only difference is the “r” defining recombinant technologies. This kind of technology enables researchers to literally combine strands of DNA that come from different sources. It is also used for producing rBST.
DNA is responsible for providing a literal blueprint or set of instructions for the growth and development of hundreds of cellular, tissue and organ cells in the body. Pieces of DNA fragments can be used to combine and create new and different strands of DNA.
While this is a scary aspect for many (think cloning), the process is quite common in regard to development of vaccines, drugs, and synthetic medications designed to “replace” or substitute a function that is not being provided by the human body.
Recombinant DNA is basically an artificial DNA strand that has been created utilizing two or more gene sequences. These combinations may or may not occur naturally, but are specifically engineered to be used in a number of applications. Like natural DNA, recombination DNA is capable of synthesizing recombinant proteins, a vital application of recombinant DNA processes.
Laboratory created rDNA is used in a variety of molecular cloning processes. The rDNA is injected in vivo into living cells of a subject. A certain part of the DNA molecule known as the cloning vector replicates inside a cell and is then used to form rDNA.
A cloning vector, at least in laboratory environments, is typically defined as a very small part of the DNA strand that contains the genetic information required for replication. Another process known as polymerase chain reaction (PCR) is a methodology often used in the replication of DNA sequences to create rDNA.
Because of the ease of manufacturer due to the recombinant potential, rHGH is used in a variety of situations for individuals diagnosed with a number of medical conditions. One use is in children diagnosed with chronic kidney disease.
It’s also been used for “catch-up growth” in transplant patients, those undergoing dialysis, and so forth. It’s also been noted that rHGH has been shown to somewhat improve height gain in children diagnosed with chronic kidney disease, noted to be most effective in prepubescent years. Find out more here.
Human growth hormone makes cells grow and replicate. It has a beneficial impact on muscle growth as well. For this reason, recombinant human growth hormone bodybuilding injections are popular among athletes for increasing muscle mass and strength, endurance, and stamina.
However, it should be noted that rHGH is on the list of forbidden substances banned by most sporting organizations, and has been since the early 1990s. This is in spite of the fact that clinical studies have yet to determine whether recombinant human growth hormone is effective in improving physical performance. Nevertheless, rHGH has the potential for increasing the anabolic effect of muscle growth.
Exercise has also been shown to naturally increase levels of HGH in the body. In the late 1980s, recombinant human growth hormone was developed via genetic engineering to reduce the risk of contamination with growth hormone injections (prior to the 1980s, HGH was retrieved from human cadavers).
It’s most commonly prescribed to patients with deficiencies of human growth hormone that not only impact stature, but a number of other supporting body functions. However, due to its anabolic properties and the belief that HGH increases lean body mass while at the same time decreasing fat mass, rHGH has been used by athletes, many of them misusing and abusing the drug. Genotropin is one of the leading brands.
Levels of HGH in the body can differ drastically depending on exercise levels, diet, time of day, and by age. Therapeutic use of rHGH technologies has been focused on childhood as well as adulthood growth hormone deficiencies. However, excessive dosage or levels of HGH in the body can contribute to a number of side effects and adverse reactions. This is especially true with the use of HGH as a doping agent.
According to studies, some athletes take much higher levels of HGH on a daily basis for up to six weeks or more at a time, which can lead to a number of adverse reactions including:
Play it safe when it comes to injecting any hormone or steroid into the body, which can negatively impact other hormone levels and metabolic processes. While recombinant human growth hormone in children and adults can provide numerous benefits (medically), use extreme caution when using it for non-medical reasons.
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